SHIRE PLC

CUSIP: B2QKY05 Class: COM

BLAIR WILLIAM & CO/IL's Holding History (CIK: 0000902367)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 25,933 Value ($000) $1,769 Avg Close — Range —
Q2 2015
Shares 3,157,487 Value ($000) $253,006 Avg Close — Range —
Q1 2015
Shares 3,200,801 Value ($000) $254,922 Avg Close — Range —
Q4 2014
Shares 2,944,582 Value ($000) $208,127 Avg Close — Range —
Q2 2014
Shares 4,711,559 Value ($000) $368,160 Avg Close — Range —
Q1 2014
Shares 4,864,543 Value ($000) $238,836 Avg Close — Range —
Q4 2013
Shares 2,177,012 Value ($000) $102,834 Avg Close — Range —
Q3 2013
Shares 312,354 Value ($000) $12,534 Avg Close — Range —
Q2 2013
Shares 375,039 Value ($000) $11,860 Avg Close — Range —